In which patients is the use of iodine-based IV contrast generally contraindicated?

The use of iodine-based intravenous (IV) contrast is generally contraindicated in pregnant women primarily due to concerns regarding fetal exposure to radiation and the potential effects of iodine on fetal development. While the risks associated with iodine-based contrast media are low in most populations, pregnancy presents unique considerations. The developing fetus is particularly vulnerable to the effects of medications and environmental agents, and therefore, when imaging is necessary, alternative imaging modalities that do not involve ionizing radiation, such as ultrasound or MRI (if appropriate), are often preferred.

Other patient groups, such as children, older adults, or those with allergies, may indeed require careful consideration when using iodine-based IV contrast due to factors like dosage adjustments, hydration needs, and managing allergic reactions. However, using this contrast agent is not universally contraindicated in those populations. In contrast, pregnancy is a clear and significant factor that necessitates a cautious approach to avoid potential harm to the fetus.